Sitagliptin Successfully Ameliorates Glycemic Control in Werner Syndrome With Diabetes
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Sitagliptin Successfully Ameliorates Glycemic Control in Werner Syndrome With Diabetes
Werner syndrome (WS) is an autosomal recessive disorder caused by a mutation in the WRN gene, and it is considered to be a representative type of progeroid syndrome (1). Patients with WS often exhibit insulin resistance, which is associated with the accumulation of visceral fat and disadipocytokinemia. We and others have previously reported that pioglitazone, a peroxisome proliferator–activated...
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Werner syndrome (WS) is a typical progeria syndrome and often leads to diabetes (1). Here, we report a case in which sitagliptin, a dipeptidyl peptidase-4 inhibitor, normalized the postprandial glucagon secretion and improved postprandial blood glucose levels. A 54-year-old female was admitted to our hospital. She developed bilateral cataracts at 35 years of age. Thereafter, at 44 years of age,...
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AIMS/INTRODUCTION Type 2 diabetes mellitus is a progressive disease that frequently requires patients to use more than one oral antihyperglycemic agent to achieve adequate glycemic control. The present multicenter, randomized study assessed the efficacy and safety of the addition of sitagliptin to ongoing voglibose monotherapy (0.2-0.3 mg three times daily) in Japanese patients with type 2 diab...
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Introduction: Diabetes is a complex disease that affects the quality of patient’s life. numerous studies have shown that quality of life in the people with diabetes is less than in people without diabetes, but, less research are discussed about the relationship between the quality of life and glycemic control. This study aimed to evaluate the health-related quality of life and its relatio...
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Objective Diabetes mellitus (DM) as a metabolic disorder is becoming a serious threat of health. In recent years, there has been renewed interest in the treatment against different diseases using medicinal plants. The present randomized clinical trial was carried out to evaluate the efficacy of Ziziphus in improving glucose control in women with type 2 diabetes mellitus (T2DM). Materials and...
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ژورنال
عنوان ژورنال: Diabetes Care
سال: 2012
ISSN: 0149-5992,1935-5548
DOI: 10.2337/dc12-1179